Thrombotic Risk DNA Panel (F5, F2, MTHFR)

Find out if you are at increased risk of thrombosis

  • Thrombophilia is a condition where the blood has an increased tendency to form clots
  • Every year, more people die from a blood clotting problem than breast cancer and AIDS combined
  • Thrombophilia can lead to complications during pregnancy
  • If you are overweight, inactive or a smoker you are at an even higher risk
  • Simple mouth swab DNA test with results in 1 – 2 weeks
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What is the Thrombotic Risk DNA Panel?

The genes most commonly associated with thrombosis are Factor V (F5), Factor II prothrombin (F2) and MTHFR. Mutations found in each of these three genes cause abnormal blood clotting. The thrombotic risk DNA panel includes the analysis of mutations in all three genes:

  • F5F5 encodes the Factor V protein that promotes blood clotting. The 1691G>A mutation in the F5 gene (known as Factor V Leiden) results in an excess of the Factor V protein and abnormal blood clotting can occur. This is the most common mutation linked to thrombophilia.
  • F2F2 encodes the prothrombin protein that promotes blood clotting. The 20210G>A mutation in the F2 gene results in an excess of the F2 prothrombin protein and abnormal blood clotting can occur.
  • MTHFRMTHFR encodes the methylenetetrahydrofolate reductase enzyme that helps process Vitamin B9. The 677C>T and 1298A>C mutations in the MTHFR gene each lead to a buildup of homocysteine that contributes to abnormal bleeding.


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The kit can be ordered online, by fax or mail, or by phone. Once you place the order, the testing kit will be shipped directly to you. The kit contains swabs called “buccal swabs”. DNA is collected quickly and easily by rubbing the swabs inside your mouth against the cheek for 30 seconds. Once the DNA is collected, the swabs are placed into the specimen container provided in the kit and returned to the laboratory for testing using the return package included in the testing kit. Once your samples arrive at the laboratory, testing begins immediately and results are available in 1 to 2 weeks.

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Symptoms of Thrombosis (Blood Clot)

Deep Vein Thrombosis (DVT)

A blood clot in a vein is the most common problem with thrombophilia. Deep Vein Thrombosis occurs when a blood clot forms in one of the deep veins of your body, usually your legs but sometimes in your arm. The signs and symptoms of DVT include:

  • Swelling in leg (or arm)
  • Heavy ache, cramping or soreness in leg (or arm)
  • Redness of the skin (particularly in back of leg below the knee)
  • Warm skin in the area of the clot

Pulmonary Embolism

Pulmonary embolism occurs when a clot that has formed in a vein breaks off and travels to the lungs. This condition can be fatal. The signs and symptoms of a pulmonary embolism include:

  • Unexplained sudden shortness of breath
  • Chest pain or discomfort which worsens when you take a deep breath or cough
  • Lightheaded, dizziness, fainting
  • Rapid heart rate

Frequently Asked Questions

Avada Admin

The Condition

What is thrombophilia? What is thrombosis? What are the conditions associated with thrombophilia?

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Avada Admin

The Test

What genes are associated with thrombophilia? Which genes and mutations are tested in the Thrombotic Risk DNA Panel? What type of sample is required for testing?

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Avada Admin

The Results

How will I receive my results? How long will testing take? What are the possible results and what are the interpretations for each result type?

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Get Started


Are you ready to get started? Print out this form and take it to your next doctor’s appointment to initiate a conversation with your doctor about Horizon carrier screening.

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Thrombophilia Learning Center

What is the treatment for Thrombophilia?

The treatment for thrombophilia depends on the type of thrombophilia and the risk of forming blood clots. The objective of the treatment is to alleviate symptoms and prevent further blood clots from developing. There are [...]

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